Endocrine Abstracts

Objective: Mounting evidence has shown an increased risk of gestational diabetes mellitus (GDM) in association with elevated exposure to air pollution. However, limited evidence is available concerning the effect of specific air pollutant(s) on GDM incidence.Methods: We conducted this case-control study on 6717 mothers with GDM diagnosed in 2006–2013 and 6717 age- and year of delivery-matched controls to further address the risk of GDM in relation t...

Background: A variety of insulin analogs have been developed and used for the treatment of diabetes mellitus. We often experience elevated serum insulin levels when insulin analog is used, and thus have difficulty in assessing insulin resistance and secretion using serum insulin results. This study aimed to investigate the differences in serum fasting insulin level and insulin antibodies according to the type of insulin analogs.Method: We conducted a ret...

Obesity is one of the leading causes of elevated cardiovascular disease (CVD) mortality and morbidity. Several indicators of abdominal obesity such as body mass index (BMI) and waist circumference (WC) are available. BMI and WC have limitations in stratifying cardio-metabolic risks. Another obesity measure, A Body Shape Index (ABSI), has been introduced but its applicability remains limited. To address this, the z-score of the log-transformed ABSI (LBSIZ) was recently develope...

Introduction: The prevalence of B-type Raf kinase (BRAFV600E) mutation in PTC has been observed in 30% to over 80%, and it seems that the mutation occurred in the early stage of thyroid carcinoma progression which precedes histological change. Based on previous reports, high body mass index (BMI) is considered a thyroid cancer risk. However, it is unclear whether high BMI has a certain association with the BRAFV600E mutational status. We assess whether high BMI is associated w...

Purpose: To evaluate the technical feasibility, efficacy, and safety of the anterolateral hydrodissection (ALHD) technique in radiofrequency ablation (RFA) for benign thyroid nodules.Methods: Between November 2019 and April 2020, 39 patients underwent 41 sessions of RFA with ALHD technique for treatment of benign thyroid nodules. ALHD was performed with cold (0°C–4°C) 5% dextrose solution during RFA to minimize pain and secure sufficient s...

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder. Aim of this audit was to assess clinical, biochemical parameters, localisation modalities and outcome in patients undergoing parathyroidectomy at University College London Hospital (UCLH).Methods: We audited all patients aged 15-years or above, undergoing parathyroidectomy, from 01-02-2018 to 31-12-2021 at UCLH via retrospective data collectio...

The regulation of insulin and glucagon secretion has traditionally been attributed to the gut-brain axis and direct sensing of blood glucose levels by pancreatic islets. However, the enteric nervous system may directly modulate pancreatic hormone release. This study focuses on a specific population of enteric neurons that exhibit the capability to transmit signals from the gut to the pancreas, potentially revealing new pathways of metabolic regulation. The gastrointestinal tra...

Background: Bardet-Biedl Syndrome (BBS) is a rare genetic disease in which impaired melanocortin-4 receptor (MC4R) signaling leads to hyperphagia and obesity. In an index Phase 3 trial, broad clinical benefit was observed in patients with BBS based on improvement or stabilization in ≥1 measure of weight, hunger, or quality of life with 1 year of treatment with the MC4R agonist setmelanotide. Reported here are long-term extension (LTE) weight outcomes after 3 years of set...

Background: Proopiomelanocortin (POMC; including biallelic variants in PCSK1) and leptin receptor (LEPR) deficiency are associated with hyperphagia and early-onset, severe obesity. Treatment with the melanocortin-4 receptor agonist setmelanotide for 1 year results in significant and sustained improvements in weight (POMC, −25.6%; LEPR, −12.5%), hunger, and quality of life. We used the metabolic syndrome Z score based on body mass index (MetS-Z-BMI) to asse...

Growth hormone (GH) therapy (GHT) requires long-term commitment to daily sc GH injections that may present adherence challenges. Patient preference and adherence have been shown to be affected by delivery devices in association with convenience of administration, level of injection-site pain, confidence in correct dose administration and satisfaction with the device. This survey investigated if switching GH device – from NordiLet/others to NordiFlex – improved pati...